Niacin (Nicotinic Acid)
SIAL/PHR1276 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Nicotinic acid; 3-Picolinic acid; Niacin; Pellagra preventive factor; Pyridine-
CAS Number: 59-67-6
Empirical Formula (Hill Notation): C6H5NO2
Molecular Weight: 123.11
EC Number: 200-441-0
MDL Number: MFCD00006391
Linear Formula: C6H5NO2
Product Type: Chemical
| agency | traceable to Ph. Eur. N0700000 |
| traceable to USP 1461003 | |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C6H5NO2/c8-6(9)5-2-1-3 |
| InChI key | PVNIIMVLHYAWGP-UHFFFAOYSA |
| mp | 236-239 °C (lit.) |
| Quality Level | 300  |
| SMILES string | OC(=O)c1cccnc1 |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Niacin (Nicotinic Acid) may be used as a secondary pharma standard for the quantification of the analyte in pharmaceutical formulations using spectrophotometric technique and reversed-phase high-performance liquid chromatography technique. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAB7604 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Niacin (Nicotinic Acid) is commonly used as a dietary supplement, and its deficiency can cause pellagra. It is involved in the synthesis of coenzymes such as NAD and NADP, which are quite essential for enzymatic reactions. As a lipid-lowering agent, it helps in the prevention of coronary heart disease, carotid artery disease and other atherosclerotic vascular diseases. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H319 |
| Precautionary statements | P280 - P305 + P351 + P338 - P337 + P313 |
| Hazard Codes | Xi |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 379.4 °F - closed cup |
| Flash Point(C) | 193 °C - closed cup |
| mp | 236-239 °C (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |