Zidovudine
SIAL/PHR1292 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 3′-Azido-3′-deoxythymidine; AZT; Azidothymidine; ZDV; Zidovudine
CAS Number: 30516-87-1
Empirical Formula (Hill Notation): C10H13N5O4
Molecular Weight: 267.24
MDL Number: MFCD00006536
Linear Formula: C10H13N5O4
Product Type: Chemical
| agency | traceable to BP 803 |
| traceable to Ph. Eur. Z1900000 | |
| traceable to USP 1724500 | |
| API family | zidovudine |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C10H13N5O4/c1-5-3-15(1 |
| InChI key | HBOMLICNUCNMMY-XLPZGREQSA |
| mp | 113-115 °C (lit.) |
| Quality Level | 300  |
| SMILES string | CC1=CN([C@H]2C[C@H](N=[N+ |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Application: | Zidovudine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations, tablets and drug dosage forms by chromatography and spectrophotometric techniques. |
| Biochem/physiol Actions: | Reverse transcriptase inhibitor active against HIV-1 virus. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA0303 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. |
| General description: | Zidovudine (AZT) is a thymidine analog anti-HIV drug, known to decrease the mortality rate in patients affected with HIV. The mode of action involves inhibiting the activity of viral reverse transcriptase and interrupting HIV replication. Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Hazard Codes | Xn |
| Risk Statements | 40 |
| Safety Statements | 36/37/39-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 113-115 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |