Nimodipine
SIAL/PHR1293 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Nimodipine; 1,4-
CAS Number: 66085-59-4
Empirical Formula (Hill Notation): C21H26N2O7
Molecular Weight: 418.44
EC Number: 266-127-0
MDL Number: MFCD00153848
Linear Formula: C21H26N2O7
Product Type: Chemical
| agency | traceable to BP 651 |
| traceable to Ph. Eur. N0850000 | |
| traceable to USP 1463858 | |
| API family | nimodipine |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C21H26N2O7/c1-12(2)30- |
| InChI key | UIAGMCDKSXEBJQ-UHFFFAOYSA |
| Quality Level | 300  |
| SMILES string | COCCOC(=O)C1=C(C)NC(C)=C( |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | Nimodipine can be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical formulations and combined dosage forms by various electrochemical and spectrophotometric techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA0583 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Nimodipine is a well-known calcium antagonist and is a moderate cerebral vasodilator, in addition to being an inhibitor of cerebrovascular reactivity. It is suggested to be cytoprotective by causing a decrease in the influx of calcium into the nerve cells. It is accepted for use in the management of delayed ischaemic dysfunction and is commonlly used in the studies of brain function impairment and dementia in old age. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264 - P270 - P301 + P312 - P501 |
| Hazard Codes | Xn |
| Risk Statements | 48/22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |