Triclosan
SIAL/PHR1338 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Triclosan; 5-
CAS Number: 3380-34-5
Empirical Formula (Hill Notation): C12H7Cl3O2
Molecular Weight: 289.54
EC Number: 222-182-2
MDL Number: MFCD00800992
Linear Formula: C12H7Cl3O2
Product Type: Chemical
| agency | traceable to USP 1682206 |
| API family | triclosan |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C12H7Cl3O2/c13-7-1-3-1 |
| InChI key | XEFQLINVKFYRCS-UHFFFAOYSA |
| Quality Level | 300  |
| SMILES string | Oc1cc(Cl)ccc1Oc2ccc(Cl)cc |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | A component of cefsulodin-irgasan-novobi |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Application: | Triclosan may be used as a pharmaceutical reference standard for the determination of the analyte in waste water samples and food stuffs by various chromatography methods. |
| Biochem/physiol Actions: | It is an inhibitor of the enoyl-ACP (acyl-carrier protein) reductase component of type II fatty acid synthase (FAS-II) in bacteria and Plasmodium. It also inhibits mammalian fatty acid synthase (FASN), and may have anticarcinogenic activity. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA9502 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Triclosan is a non-ionic broad spectrum antibacterial and antifungal agent, used in personal care products such as antiseptic soaps, toothpastes, fabrics and plastics. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H410 |
| Precautionary statements | P273 - P302 + P352 - P305 + P351 + P338 |
| Hazard Codes | Xi,N |
| Risk Statements | 36/38-50/53 |
| Safety Statements | 26-39-46-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |