Glutathione
SIAL/PHR1359 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: L-Glutathione reduced; γ-L-Glutamyl-L-cysteinyl-glycine; GSH
CAS Number: 70-18-8
Empirical Formula (Hill Notation): C10H17N3O6S
Molecular Weight: 307.32
EC Number: 200-725-4
MDL Number: MFCD00065939
Linear Formula: H2NCH(CO2H)CH2CH2CONHCH(CH2SH)CONHCH2CO2H
Product Type: Chemical
| agency | traceable to Ph. Eur. Y0000517 |
| traceable to USP 1294820 | |
| API family | glutathione |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C10H17N3O6S/c11-5(10(1 |
| InChI key | RWSXRVCMGQZWBV-WDSKDSINSA |
| mp | 192-195 °C (dec.) (lit.) |
| Quality Level | 300  |
| SMILES string | N[C@@H](CCC(=O)N[C@@H](CS |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Amino Acid Sequence: | γ-Glu-Cys-Gly |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available. |
| Application: | May be used at 5-10 mM to elute glutathione S-transferase (GST) from glutathione agarose. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst. Glutathione-S-transferase catalyzes the formation of glutathione thioethers with xenobiotics, leukotrienes, and other molecules that have an electrophilic center. Glutathione also forms disulfide bonds with cysteine residues in proteins. Via these mechanisms, it can have the paradoxical effect of reducing the efficacy of anti-cancer agents. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA7940 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Glutathione (GSH) is the most important nonprotein thiol widely distributed in animal tissues, plants, and microorganisms. GSH is also a key determinant of redox signaling and protection against oxidative stress. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 192-195 °C (dec.) (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |