Cyclophosphamide
SIAL/PHR1404 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Cyclophosphamide monohydrate; 2-
CAS Number: 6055-19-2
Empirical Formula (Hill Notation): C7H15Cl2N2O2P · H2O
Molecular Weight: 279.10
EC Number: 200-015-4
MDL Number: MFCD00149395
Linear Formula: C7H15Cl2N2O2P · H2O
Product Type: Chemical
| agency | traceable to Ph. Eur. C3250000 |
| traceable to USP 1157002 | |
| API family | cyclophosphamide |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C7H15Cl2N2O2P.H2O/c8-2 |
| InChI key | PWOQRKCAHTVFLB-UHFFFAOYSA |
| mp | 49-51 °C (lit.) |
| packaging | pkg of 1 g |
| Quality Level | 300  |
| SMILES string | [H]O[H].ClCCN(CCCl)P1(=O) |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | Cyclophosphamide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC0295 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cyclophosphamide is one of the cytostatic compounds that is a constituent of several polychemotherapy regimens. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H301 - H340 - H350 - H360FD |
| Precautionary statements | P202 - P264 - P270 - P280 - P301 + P310 - P405 |
| Hazard Codes | T |
| Risk Statements | 45-25 |
| Safety Statements | 53-45 |
| RIDADR | UN 3464 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 49-51 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |