Chloramphenicol
SIAL/PHR1412 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Chloramphenicol; D-(-)-threo-2,2-Dichloro-N-[β-hydroxy-α−(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide; D-(-)-threo-
EC Number: 200-287-4
Product Type: Chemical
| agency | traceable to BP 854 |
| traceable to Ph. Eur. C1200000 | |
| traceable to USP 1107004 | |
| API family | chloramphenicol |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| Quality Level | 300  |
| storage temp. | -10 to -25°C |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Mode of Action:Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription Mode of Resistance:Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it. Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA2476 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is widely used against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Preparation Note: | Stock solutions can be prepared directly in the vial at any recommended concentration. A solution at 50 mg/mL in ethanol yields a clear, very faint, yellow solution. Degradation of chloramphenicol in aqueous solution is catalyzed by general acids and bases. This rate of degradation is independent of the ionic strength and pH. |
| Suitability: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. |
| Symbol |   GHS05,GHS08 |
| Signal word | Danger |
| Hazard statements | H318 - H351 - H361fd |
| Precautionary statements | P202 - P280 - P305 + P351 + P338 - P308 + P313 - P405 - P501 |
| Hazard Codes | T |
| Risk Statements | 45 |
| Safety Statements | 53-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | -10 to -25°C |
| UNSPSC | 41116107 |