Chlorhexidine
SIAL/PHR1421 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Chlorhexidine; 1,1′-Hexamethylenebis[5-(4-chlorophenyl)biguanide]
CAS Number: 55-56-1
Empirical Formula (Hill Notation): C22H30Cl2N10
Molecular Weight: 505.45
EC Number: 200-238-7
MDL Number: MFCD00009673
Linear Formula: [-(CH2)3NHC(=NH)NHC(=NH)NHC6H4Cl]2
Product Type: Chemical
| agency | traceable to Ph. Eur. C1510000 |
| traceable to USP 1111001 | |
| API family | chlorhexidine |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C22H30Cl2N10/c23-15-5- |
| InChI key | GHXZTYHSJHQHIJ-UHFFFAOYSA |
| mp | 134-136 °C (lit.) |
| Quality Level | 300  |
| SMILES string | Clc1ccc(NC(=N)NC(=N)NCCCC |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | Chlorhexidine may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC3899 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Chlorhexidine, the most popular antiseptic of biguanides, acts as a potential antimicrobial agent against several gram-positive and a few gram-negative bacteria. It is prescribed as a medicine for the prevention and treatment of the redness, swelling, and bleeding gums associated with gingivitis in humans. It may also be used as a general-purpose disinfectant for cleansing wounds, skin, instrument, and equipment in veterinary applications. Other applications of chlorhexidine include its use as the component of shampoos, ointments, skin and wound cleansers etc. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |   GHS05,GHS09 |
| Signal word | Danger |
| Hazard statements | H318 - H410 |
| Precautionary statements | P273 - P280 - P305 + P351 + P338 - P391 - P501 |
| Hazard Codes | Xi,N |
| Risk Statements | 36/37/38-43-50/53 |
| Safety Statements | 26-36/37-60-61 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 134-136 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |