Temozolomide

SIAL/PHR1437 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Temozolomide; 3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide; 3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide; 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide; 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one; NSC 362856

CAS Number: 85622-93-1
Empirical Formula (Hill Notation): C₆H₆N₆O₂
Molecular Weight: 194.15
MDL Number: MFCD00866492
Linear Formula: C₆H₆N₆O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1437-1G	1 g	$174.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to USP 1643543
API family	temozolomide
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C6H6N6O2/c1-11-6(14)12-2-8-3(4(7)13)5(12)9-10-11/h2H,1H3,(H2,7,13)
InChI key	BPEGJWRSRHCHSN-UHFFFAOYSA-N
packaging	pkg of 1 g
Quality Level	300
SMILES string	CN1N=Nc2c(ncn2C1=O)C(N)=O
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	Temozolomide may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by reverse phase liquid chromatography and UV spectrophotometry.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAA2745 in the slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Temozolomide is an alkylating agent of the imidazotetrazine group. It is a chemotherapy drug, used in the treatment of anaplastic astrocytoma, glioblastoma multiforme and malignant metastatic melanoma, which works by arresting cancer cell growth.
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H315 - H319 - H335 - H340 - H350 - H360
Precautionary statements	P201 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Codes	T
Risk Statements	45-46-60-61-22-36/37/38
Safety Statements	53-26-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	41116107

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