Kanamycin Sulfate

SIAL/PHR1487 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Kanamycin sulfate from Streptomyces kanamyceticus; Kanamycin A; Kanamycin sulfate salt

CAS Number: 25389-94-0
Empirical Formula (Hill Notation): C₁₈H₃₆N₄O₁₁ · H₂O₄S
Molecular Weight: 582.58
EC Number: 246-933-9
MDL Number: MFCD00070253
Linear Formula: C₁₈H₃₆N₄O₁₁ · H₂O₄S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1487-500MG	500 mg	$105.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to BP 861
	traceable to Ph. Eur. K0200000
	traceable to USP 1355006
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1
InChI key	OOYGSFOGFJDDHP-KMCOLRRFSA-N
packaging	pkg of 500 mg
Quality Level	300
SMILES string	OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	Kanamycin Sulfate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions:	Mode of Action: The product acts by binding to the 70S ribosomal subunit, inhibiting translocation and eliciting miscoding. Mode of Resistance:Aminoglycoside-modifying enzymes (including acetyltransferase, phosphotransferase, nucleotidyltransferase) can alter this antibiotic, preventing its interaction with ribosomes. Antimicrobial spectrum: Kanamycin sulfate is effective against gram-negative and gram-postiive bacteria, and mycoplasma.
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAB7808 in the slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Kanamycin Sulfate, generated by specific strains of Streptomyces kanamyceticus, belongs to the class of aminoglycoside antibiotics. It is known to act effectively against a broad spectrum of Gram-negative and Gram-positive bacteria.
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Symbol	GHS08
Signal word	Danger
Hazard statements	H360
Precautionary statements	P201 - P308 + P313
Hazard Codes	T
Risk Statements	61
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	41116107

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