Dexamethasone Acetate

SIAL/PHR1527 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Dexamethasone 21-acetate; 9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate; 9α-Fluoro-16α-methylprednisolone-21-acetate; Prednisolone F acetate

CAS Number: 1177-87-3
Empirical Formula (Hill Notation): C₂₄H₃₁FO₆
Molecular Weight: 434.50
EC Number: 214-646-8
MDL Number: MFCD00027407
Linear Formula: C₂₄H₃₁FO₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1527-1G	1 g	$124.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	BP
	EP
	traceable to Ph. Eur. D0710000
	traceable to USP 1176506
	USP
API family	dexamethasone
application(s)	pharmaceutical (small molecule)
biological source	synthetic
CofA	current certificate can be downloaded
color	white
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C24H31FO6/c1-13-9-18-17-6-5-15-10-16(27)7-8-21(15,3)23(17,25)19(28)11-22(18,4)24(13,30)20(29)12-31-14(2)26/h7-8,10,13,17-19,28,30H,5-6,9,11-12H2,1-4H3/t13-,17+,18+,19+,21+,22+,23+,24+/m1/s1
InChI key	AKUJBENLRBOFTD-RPRRAYFGSA-N
mp	460.4-464 °F (238—240°C)
packaging	pkg of 1 g
Quality Level	300
shipped in	ambient
SMILES string	[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COC(C)=O
solubility	acetone: freely soluble
	dichloromethane: slightly soluble
	methanol: freely soluble
	water: practically insoluble
storage condition	protect from light (20 mm aluminium crimp seal for unused portion)
storage temp.	2-30°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable
vapor pressure	<0.0000001 kPa ( 25 °C)

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	Dexamethasone acetate is used as a pharmaceutical reference standard for the quantification the analyte in pharmaceutical formulations using liquid chromatography (LC) technique.
Application:	Dexamethasone Acetate may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAA3645 in the slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Dexamethasone acetate (Decadron-LA) belongs to the class of long-acting glucocorticoids. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
General description:	Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Dexamethasone Acetate is a steroid used for the treatment of various diseases because of its anti-inflammatory and inmunosuppresor effects. It is a common component of ointments, creams, lotions, aerosols and microemulsions.
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Recommended products:	Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial .

Symbol	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280
Hazard Codes	Xi
Risk Statements	43
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	460.4-464 °F (238—240°C)
Storage Temp.	2-30°C
UNSPSC	41116107

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