Tetrahydrofuran
SIAL/PHR1561 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Tetrahydrofuran; Butylene oxide; Oxolane; Tetramethylene oxide
CAS Number: 109-99-9
Empirical Formula (Hill Notation): C4H8O
Molecular Weight: 72.11
EC Number: 203-726-8
MDL Number: MFCD00005356
Linear Formula: C4H8O
Product Type: Chemical
| agency | traceable to USP 1601770 |
| application(s) | pharmaceutical (small molecule) |
| autoignition temp. | 610 °F |
| bp | 65-67 °C (lit.) |
| CofA | current certificate can be downloaded |
| density | 0.889 g/mL at 25 °C (lit.) |
| expl. lim. | 1.8-11.8 % |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C4H8O/c1-2-4-5-3-1/h1- |
| InChI key | WYURNTSHIVDZCO-UHFFFAOYSA |
| mp | −108 °C (lit.) |
| packaging | ampule of 3x1.2 mL each |
| Quality Level | 300  |
| refractive index | n |
| SMILES string | C1CCOC1 |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable | |
| vapor density | 2.5 (vs air) |
| vapor pressure | 114 mmHg ( 15 °C) |
| 143 mmHg ( 20 °C) |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC0275 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Tetrahydrofuran is a saturated cyclic ether with a potential use as a biofuel. It is used for the manufacture of polyurethanes. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |    GHS02,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225 - H302 - H319 - H335 - H336 - H351 |
| Precautionary statements | P201 - P202 - P210 - P301 + P312 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | F,Xn |
| Risk Statements | 11-19-36/37-40 |
| Safety Statements | 13-16-29-33-36-37-46 |
| RIDADR | UN 2056 3 / PGII |
| WGK Germany | WGK 1 |
| Flash Point(F) | -6.2 °F - closed cup |
| Flash Point(C) | -21.2 °C - closed cup |
| Supplemental Hazard Statements | EUH018 - EUH019 |
| bp | 65-67 °C (lit.) |
| mp | −108 °C (lit.) |
| Density | 0.889 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |