D4 Cyclomethicone
SIAL/PHR1565 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Octamethylcyclotetrasiloxane
CAS Number: 556-67-2
Empirical Formula (Hill Notation): C8H24O4Si4
Molecular Weight: 296.62
EC Number: 209-136-7
MDL Number: MFCD00003269
Linear Formula: [-Si(CH3)2O-]4
Product Type: Chemical
| agency | traceable to USP 1154707 |
| API family | cyclomethicone |
| application(s) | pharmaceutical (small molecule) |
| bp | 175-176 °C (lit.) |
| CofA | current certificate can be downloaded |
| density | 0.956 g/mL at 25 °C (lit.) |
| form | liquid |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C8H24O4Si4/c1-13(2)9-1 |
| InChI key | HMMGMWAXVFQUOA-UHFFFAOYSA |
| mp | 17-18 °C (lit.) |
| packaging | pkg of 500 mg |
| Quality Level | 300  |
| refractive index | n |
| SMILES string | C[Si]1(C)O[Si](C)(C)O[Si] |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable | |
| vapor density | 1 (vs air) |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | D4 Cyclomethicone may be used as a pharmaceutical reference standard for the determination of the analyte in personal care formulations by gas chromatography. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC2961 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | D4 Cyclomethicone is a cyclic siloxane, that has a silicon-oxygen bond in a cyclic arrangement and methyl groups attached with the silicon atom. It is used in the production of some silicon-based polymers that are widely used in various personal care products. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Symbol |   GHS02,GHS08 |
| Signal word | Warning |
| Hazard statements | H226 - H361f - H413 |
| Precautionary statements | P201 - P202 - P210 - P233 - P273 - P308 + P313 |
| Hazard Codes | Xn |
| Risk Statements | 10-53-62 |
| Safety Statements | 36/37-46-51-61 |
| RIDADR | UN 1993C 3 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 123.8 °F - closed cup |
| Flash Point(C) | 51 °C - closed cup |
| bp | 175-176 °C (lit.) |
| mp | 17-18 °C (lit.) |
| Density | 0.956 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |