Pemetrexed

SIAL/PHR1596 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Pemetrexed disodium heptahydrate

CAS Number: 357166-29-1
Empirical Formula (Hill Notation): C₂₀H₁₉N₅Na₂O₆ · 7H₂O
Molecular Weight: 597.48
Linear Formula: C₂₀H₁₉N₅Na₂O₆ · 7H₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-PHR1596-500MG	500 mg	$105.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to Ph. Eur. Y0001539
API family	pemetrexed
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C20H21N5O6.2Na.7H2O/c21-20-24-16-15(18(29)25-20)12(9-22-16)6-3-10-1-4-11(5-2-10)17(28)23-13(19(30)31)7-8-14(26)27;;;;;;;;;/h1-2,4-5,9,13H,3,6-8H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29);;;71H2/q;2+1;;;;;;;/p-2/t13-;;;;;;;;;/m0........./s1
InChI key	QJVSMHJWAOSBMD-MYXYZBIASA-L
packaging	pkg of 500 mg
Quality Level	300
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAA4712 in the slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Pemetrexed is an anionic anticancer drug with a narrow therapeutic index. As a folate anti metabolite, it acts as an inhibitor of thymidylate synthase. It can act effectively against a broad-spectrum of solid tumors such as non-small-cell lung and breast cancers in clinical trials. It is also effective against both dihydrofolate reductase and glycinamide ribonucleotide formyl transferase.
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H315 - H319 - H341 - H360FD - H372
Precautionary statements	P202 - P260 - P264 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	41116107

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