Levothyroxine

SIAL/PHR1613 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: L-Thyroxine; 3,3′,5,5″-Tetraiodo-L-thyronine; 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine; T₄

CAS Number: 51-48-9
Empirical Formula (Hill Notation): C₁₅H₁₁I₄NO₄
Molecular Weight: 776.87
EC Number: 200-101-1
MDL Number: MFCD00002595
Linear Formula: HOC₆H₂(I)₂OC₆H₂(I)₂CH₂CH(NH₂)CO₂H
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1613-1G	1 g	$105.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to Ph. Eur. L0570000
	traceable to USP 1365000
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
InChI key	XUIIKFGFIJCVMT-LBPRGKRZSA-N
mp	223 °C (dec.) (lit.)
packaging	pkg of 1 g
Quality Level	300
SMILES string	N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O
storage temp.	2-30°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	Levothyroxine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations and bulk dosage forms and oral liquid formulations by chromatography.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions:	L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and, thus, protein synthesis.
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAC1514 in the slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Levothyroxine is a thyroid hormone that is responsible for the physiological actions such as growth, cardiac functionality, and regulation of carbohydrates, lipid, and protein metabolisms. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	223 °C (dec.) (lit.)
Storage Temp.	2-30°C
UNSPSC	41116107

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