Cisplatin
SIAL/PHR1624 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: cis-Diammineplatinum(II) dichloride; cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; Cisplatin
CAS Number: 15663-27-1
Empirical Formula (Hill Notation): H6Cl2N2Pt
Molecular Weight: 300.05
EC Number: 239-733-8
MDL Number: MFCD00011623
Linear Formula: Pt(NH3)2Cl2
Product Type: Chemical
| agency | traceable to Ph. Eur. C2210000 |
| traceable to USP 1134357 | |
| API family | cisplatin |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/2ClH.2H3N.Pt/h2*1H;2*1 |
| InChI key | LXZZYRPGZAFOLE-UHFFFAOYSA |
| mp | 270 °C (lit.) |
| packaging | pkg of 200 mg |
| Quality Level | 300  |
| SMILES string | N.N.Cl[Pt]Cl |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | Cisplatin may be used as an analytical reference standard for the determination of the analyte in plasma, cancer cell, and tumor samples by high-performance liquid chromatographic assay. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAB7778 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cisplatin is an antineoplastic drug used for the treatment of cancer patients with a variety of different malignancies. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300 - H315 - H317 - H319 - H334 - H335 - H350 |
| Precautionary statements | P201 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 |
| Hazard Codes | T |
| Risk Statements | 45-25-41 |
| Safety Statements | 53-26-39-45 |
| RIDADR | UN 3288 6.1 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 270 °C (lit.) |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |