Tolfenamic Acid
SIAL/PHR1629 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Tolfenamic acid; 2 (3-
CAS Number: 13710-19-5
Empirical Formula (Hill Notation): C14H12ClNO2
Molecular Weight: 261.70
EC Number: 237-264-3
MDL Number: MFCD00133865
Linear Formula: C14H12ClNO2
Product Type: Chemical
| agency | traceable to Ph. Eur. Y0000154 |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C14H12ClNO2/c1-9-11(15 |
| InChI key | YEZNLOUZAIOMLT-UHFFFAOYSA |
| packaging | pkg of 500 mg |
| Quality Level | 300  |
| SMILES string | Cc1c(Cl)cccc1Nc2ccccc2C(O |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Application: | Tolfenamic Acid may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using anionic capillary isotachophoresis (ITP) technique. |
| Biochem/physiol Actions: | Non-steroidal anti-inflammatory agent. Interferes with synthesis of β-amyloid precursor protein, and thus Aβ peptides, by promoting degradation of an essential transcription factor. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA5493 in the slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Tolfenamic Acid is an anthranilic acid derivative and a non-steroidal anti-inflammatory drug (NSAID). Its applications in treating pancreatic, esophageal, colorectal and lung cancer is being investigated. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |