Cetirizine Hydrochloride
SIAL/PHR1656 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Cetirizine dihydrochloride; 2-
CAS Number: 83881-52-1
Empirical Formula (Hill Notation): C21H25ClN2O3 · 2HCl
Molecular Weight: 461.81
MDL Number: MFCD00941428
Linear Formula: C21H25ClN2O3 · 2HCl
Product Type: Chemical
agency | traceable to BP 837 |
traceable to Ph. Eur. C0980650 | |
traceable to USP 1102929 | |
application(s) | pharmaceutical (small molecule) |
CofA | current certificate can be downloaded |
format | neat |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C21H25ClN2O3.2ClH/c22- |
InChI key | PGLIUCLTXOYQMV-UHFFFAOYSA |
packaging | pkg of 1 g |
Quality Level | 300 ![]() |
SMILES string | OC(COCCN1CCN(C(C2=CC=C(Cl |
storage temp. | 2-30°C |
technique(s) | gas chromatography (GC): suitable |
HPLC: suitable |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Application: | Cetirizine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques. |
Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
Biochem/physiol Actions: | Cetirizine hydrochloride is an orally active and selective H1-receptor antagonist. Antihistaminic; Piperazines. Non-sedating type histamine H1-receptor antagonist; major metabolite of hydroxyzine. Pharmacological activity resides primarily in the (R)-isomer. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA5757 in the slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cetirizine hydrochloride, a second generation antihistaminic drug, is one of the carboxylated metabolites of hydroxyzine that can typically bind to histamine H1 receptor. It is effective against diseases such as urticaria, angioedema, allergies and hay fever. |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-30°C |
UNSPSC | 41116107 |