Propofol
SIAL/PHR1663 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 2,6-
CAS Number: 2078-54-8
Empirical Formula (Hill Notation): C12H18O
Molecular Weight: 178.27
EC Number: 218-206-6
MDL Number: MFCD00008885
Linear Formula: [(CH3)2CH]2C6H3OH
Product Type: Chemical
| agency | traceable to BP 1031 |
| traceable to Ph. Eur. Y0000016 | |
| traceable to USP 1572503 | |
| API family | propofol |
| application(s) | pharmaceutical (small molecule) |
| bp | 256 °C/764 mmHg (lit.) |
| CofA | current certificate can be downloaded |
| density | 0.962 g/mL at 25 °C (lit.) |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C12H18O/c1-8(2)10-6-5- |
| InChI key | OLBCVFGFOZPWHH-UHFFFAOYSA |
| mp | 18 °C (lit.) |
| packaging | ampule of 1 mL |
| Quality Level | 300  |
| refractive index | n |
| SMILES string | CC(C)c1cccc(C(C)C)c1O |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable | |
| vapor pressure | 5.6 mmHg ( 100 °C) |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Propofol may be used as a pharmaceutical reference standard for the determination of the analyte in emulsion dosage form by sequential injection technique with spectrophotometric and fluorimetric detections. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA5999 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Propofol is approved for induction and maintenance of paediatric anesthesia and sedation in children less than 3 years of age. The mechanism of action involves interaction with gamma-aminobutyric acid A receptor. Rapid effect and fewer side effects like postoperative nausea makes propofol a popular intravenous anesthetic agents. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Symbol |  GHS07,GHS07 |
| Signal word | Warning-Warning |
| Hazard statements | H302 - H315 - H319 - H335 - H302 - H315 - H319 - H335 |
| Precautionary statements | P261 - P264 - P270 - P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P301 + P312 - P302 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | 235.4 °F - closed cup |
| Flash Point(C) | 113 °C - closed cup |
| bp | 256 °C/764 mmHg (lit.) |
| mp | 18 °C (lit.) |
| Density | 0.962 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |