Famciclovir
SIAL/PHR1696 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Famciclovir; 2-
CAS Number: 104227-87-4
Empirical Formula (Hill Notation): C14H19N5O4
Molecular Weight: 321.33
MDL Number: MFCD00866964
Linear Formula: C14H19N5O4
Product Type: Chemical
| agency | traceable to USP 1269152 |
| API family | famciclovir |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C14H19N5O4/c1-9(20)22- |
| InChI key | GGXKWVWZWMLJEH-UHFFFAOYSA |
| packaging | pkg of 1 g |
| Quality Level | 300  |
| SMILES string | CC(=O)OCC(CCn1cnc2cnc(N)n |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | Famciclovir may be used as a reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry and high performance liquid chromatography. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Famciclovir is an antiretroviral guanosine analog used to treat herpesvirus infections and hepatitis B. Famciclovir is rapidly converted to penciclovir. Viral thymidine kinase phosphorylates penciclovir to a monophosphate form that celular kinases convert in turn to penciclovir triphosphate. Penciclovir triphosphate competitively inhibits viral DNA polymerase and thus viral replication. Prolonged administration can lead to resistance; it is often manifested as selection of pre-existing resistant strains with mutations in the reverse transcriptase domain of the DNA polymerase gene. |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC3254 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Famciclovir is an antiviral drug, which is predominantly used in the treatment of herpes virus infection. It is an inactive prodrug, which on administration, undergoes rapid biotransformation to penciclovir. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Recommended products: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 41116107 |