Buprenorphine Hydrochloride

SIAL/PHR1729 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Buprenorphine hydrochloride; [5α,7α(S)]-17-(Cyclopropylmethyl)-α-(1,1-dimethylethyl)4,5-epoxy-18,19-dihydo-3-hydroxy-6-methoxy-α-methyl-6,14-ethenomorphinan-7-methanol hydrochloride

CAS Number: 53152-21-9
Empirical Formula (Hill Notation): C₂₉H₄₁NO₄ · HCl
Molecular Weight: 504.10
EC Number: 258-396-8
MDL Number: MFCD00084836
Linear Formula: C₂₉H₄₁NO₄ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1729-50MG	50 mg	$267.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to Ph. Eur. Y0001109
	traceable to USP 1078700
API family	buprenorphine
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
drug control	USDEA Schedule III; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIC (Portugal)
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C29H41NO4.ClH/c1-25(2,3)26(4,32)20-15-27-10-11-29(20,33-5)24-28(27)12-13-30(16-17-6-7-17)21(27)14-18-8-9-19(31)23(34-24)22(18)28;/h8-9,17,20-21,24,31-32H,6-7,10-16H2,1-5H3;1H/t20-,21-,24-,26+,27-,28+,29-;/m1./s1
InChI key	UAIXRPCCYXNJMQ-RZIPZOSSSA-N
packaging	pkg of 50 mg
Quality Level	300
SMILES string	Cl[H].CO[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O)c6O[C@@H]2[C@]3(CCN4CC7CC7)c56
storage temp.	2-30°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	Buprenorphine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography method.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions:	Full agonist at ORL1 receptors, antagonist or partial agonist at μ, κ, and δ opioid receptors.
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAA7438 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Buprenorphine Hydrochloride is a potent long-acting synthetic opiate analgesic.
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 - H361
Precautionary statements	P201 - P301 + P312 + P330 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-30°C
UNSPSC	41116107

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