Colchicine
SIAL/PHR1764 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Colchicine; (S)-N-
CAS Number: 64-86-8
Empirical Formula (Hill Notation): C22H25NO6
Molecular Weight: 399.44
EC Number: 200-598-5
MDL Number: MFCD00078484
Linear Formula: C22H25NO6
Product Type: Chemical
| agency | traceable to BP 1150 |
| traceable to Ph. Eur. C2580000 | |
| traceable to USP 1146006 | |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C22H25NO6/c1-12(24)23- |
| InChI key | IAKHMKGGTNLKSZ-INIZCTEOSA |
| mp | 150-160 °C (dec.) (lit.) |
| packaging | pkg of 400 mg |
| Quality Level | 300  |
| SMILES string | COC1=CC=C2C(=CC1=O)[C@H]( |
| storage temp. | 2-8°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. Colchicine may be used as a pharmaceutical reference standard for the determination of colchicine in human plasma at therapeutic concentrations by liquid chromatography–tandem mass spectrometry method. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Colchicine is a drug used for the treatment of gout and certain rheumatic and nonrheumatic conditions. It is the major alkaloid in the plant Colchicum autumnale (meadow saffron). |
| Symbol |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300 - H340 |
| Precautionary statements | P201 - P301 + P310 + P330 |
| RIDADR | UN 1544PSN1 6.1 / PGI |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 150-160 °C (dec.) (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |