Digoxin

SIAL/PHR1771 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Digoxin; 12β-Hydroxydigitoxin

CAS Number: 20830-75-5
Empirical Formula (Hill Notation): C₄₁H₆₄O₁₄
Molecular Weight: 780.94
EC Number: 244-068-1
MDL Number: MFCD00003674
Linear Formula: C₄₁H₆₄O₁₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-PHR1771-300MG	300 mg	$267.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to Ph. Eur. D1900000
	traceable to USP 1200000
API family	digoxin
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1
InChI key	LTMHDMANZUZIPE-PUGKRICDSA-N
packaging	pkg of 300 mg
Quality Level	300
SMILES string	C[C@H]1O[C@H](C[C@H](O)[C@@H]1O)O[C@H]2[C@@H](O)C[C@@H](O[C@@H]2C)O[C@H]3[C@@H](O)C[C@@H](O[C@@H]3C)O[C@H]4CC[C@@]5(C)[C@H](CC[C@@H]6[C@@H]5C[C@@H](O)[C@]7(C)[C@H](CC[C@]67O)C8=CC(=O)OC8)C4
storage temp.	2-30°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	Digoxin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and plasma samples by various chromatography techniques.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions:	A cardiac glycoside, substrate for Pgp, upregulates Pgp expression and down regulates SXR (Steroid Xenobiotic Receptor).
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAA8515 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Digoxin is one of the digitalis glycosides, extensively utilized for the treatment of congestive heart failure (CHF). It exhibits positive inotropic effects, antiarrhythmic as well as vasoconstrictor actions. It is reported that digoxin and other cardiac glycosides could play important role in the prevention and/or treatment of proliferative diseases like cancer.
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 - H331 - H373
Precautionary statements	P260 - P264 - P270 - P301 + P310 - P304 + P340 + P311 - P314
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3

Storage Temp.	2-30°C
UNSPSC	41116107

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