Doxorubicin Hydrochloride

SIAL/PHR1789 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Doxorubicin hydrochloride; DOX; Hydroxydaunorubicin hydrochloride

CAS Number: 25316-40-9
Empirical Formula (Hill Notation): C₂₇H₂₉NO₁₁ · HCl
Molecular Weight: 579.98
EC Number: 246-818-3
MDL Number: MFCD00077757
Linear Formula: C₂₇H₂₉NO₁₁ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1789-200MG	200 mg	$426.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to BP 990
	traceable to Ph. Eur. D2975000
	traceable to USP 1225703
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
form	powder
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key	MWWSFMDVAYGXBV-RUELKSSGSA-N
mp	216 °C (dec.) (lit.)
packaging	pkg of 200 mg
Quality Level	300
SMILES string	Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
storage temp.	-10 to -25°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	This pharmaceutical secondary standard can also be used as follows:• Development of a reversed-phase high-performance liquid chromatographic (RP-HPLC) method combined with UV detection to determine doxorubicin hydrochloride in plasma samples • Electrochemical determination of doxorubicin by spinel-structured cobalt ferrite (CoFe₂O₄) modified carbon paste electrode in biological fluid and injection samples • Determination of doxorubicin hydrochloride in human plasma samples using a graphene quantum dots (GQDs) based electrochemical sensor • RP-HPLC method-based quantitative analysis of doxorubicin hydrochloride in vacuum foam dried formulations • Voltammetric determination of doxorubicin hydrochloride and dastinib using zinc oxide (ZnO) nanoparticle/1-butyl-3-methylimidazolium tetra-fluoroborate modified carbon paste electrode (ZnO-NPs/BMTFB/CPE) in their combined injection samples
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAB3692 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
General description:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Doxorubicin Hydrochloride is an anthracycline antibiotic, known for its broad range anti-cancer activities.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H340 - H350 - H360FD
Precautionary statements	P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	216 °C (dec.) (lit.)
Storage Temp.	-10 to -25°C
UNSPSC	41116107

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