Imipramine Hydrochloride
SIAL/PHR1797 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Imipramine hydrochloride; IMI; 10,11-
CAS Number: 113-52-0
Empirical Formula (Hill Notation): C19H24N2 · HCl
Molecular Weight: 316.87
EC Number: 204-030-7
MDL Number: MFCD00012669
Linear Formula: C19H24N2 · HCl
Product Type: Chemical
| agency | traceable to BP 932 |
| traceable to Ph. Eur. I0100000 | |
| traceable to USP 1338007 | |
| API family | imipramine |
| application(s) | pharmaceutical (small molecule) |
| CofA | current certificate can be downloaded |
| format | neat |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C19H24N2.ClH/c1-20(2)1 |
| InChI key | XZZXIYZZBJDEEP-UHFFFAOYSA |
| packaging | pkg of 1 g |
| Quality Level | 300  |
| SMILES string | Cl[H].CN(C)CCCN1c2ccccc2C |
| storage temp. | 2-30°C |
| technique(s) | gas chromatography (GC): suitable |
| HPLC: suitable |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: | Imipramine Hydrochloride may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography and spectrophotometry techniques. |
| Application: | These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: | Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with Kis of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (Ki = 25 μM). |
| Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA8623 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: | Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Imipramine Hydrochloride is typically utilized for the treatment of depressive disorders due to its efficiency in uplifting the patients′ mood by interfering in the reuptake of norepinephrine or serotonin. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |  GHS06,GHS06 |
| Signal word | Danger;Danger |
| Hazard statements | H300 - H300 |
| Precautionary statements | P264 - P270 - P301 + P310 - P301 + P310 + P330 - P405 - P501 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-30°C |
| UNSPSC | 41116107 |