Synonym: Metamizole sodium hydrate; (antipyrinylmethylamino)methanesulfonic acid sodium salt; 1-Phenyl-2,3-dimethyl-5-pyrazolone-4-methylaminomethanesulfonate sodium; 4-Methylamino-1,5-dimethyl-2-phenyl-3-pyrazolone sodium methanesulfonate; Analgin; Dipyrone; Metamizol; Methampyrone; Methylmelubrin; Noraminopyrine methanesulfonate sodium; Sodium methylaminoantipyrine methanesulfonate; Sulpyrine; [(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)methylamino]methanesulfonic acid sodium salt
CAS Number: 5907-38-0
Empirical Formula (Hill Notation): C13H16N3O4S · Na · H2O
Molecular Weight: 351.35
Linear Formula: C13H16N3O4S · Na · H2O
Product Type: Chemical
| agency |
traceable to Ph. Eur. M0600900 |
| API family |
metamizole |
| application(s) |
pharmaceutical (small molecule) |
| CofA |
current certificate can be downloaded |
| form |
solid |
| grade |
certified reference material |
| |
pharmaceutical secondary standard |
| InChI |
1S/C13H17N3O4S.Na.H2O/c1-10-12(14(2)9-21(18,19)20)13(17)16(15(10)3)11-7-5-4-6-8-11;;/h4-8H,9H2,1-3H3,(H,18,19,20);;1H2/q;+1;/p-1 |
| InChI key |
UNZIDPIPYUMVPA-UHFFFAOYSA-M |
| packaging |
pkg of 100 mg |
| Quality Level |
300  |
| storage temp. |
2-8°C |
| technique(s) |
gas chromatography (GC): suitable |
| |
HPLC: suitable |
| Analysis Note: |
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: |
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: |
Metamizole (Dipyrone) is a potent analgesic and antipyretic. Metamizole inhibits prostaglandin synthesis in both the periphery and the central nervous system. Metamizole may act as a prodrug. It is rapidly hydrolyzed to N-methyl-4-aminoantipyrine (MAA) and 4-aminoantipyrine (AA) which inhibit cyclo-oxygenase activity and can be further acylated with arachidonic acid forming compounds that bind to central and peripheral cannabinoid (CB1 and CB2) receptors and TRPV1 receptors. It is believed that these metabolites play a major role in metamizole activity. Metamizole has been withdrawn from clinical use in several countries because of a side-effect of agranulocytosis in some patients. |
| Footnote: |
To see an example of a Certificate of Analysis for this material enter LRAC2806 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
| Other Notes: |
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Recommended products: |
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Storage Temp. |
2-8°C |
| UNSPSC |
41116107 |
GHS08