Paclitaxel

SIAL/PHR1803 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Paclitaxel

CAS Number: 33069-62-4
Empirical Formula (Hill Notation): C₄₇H₅₁NO₁₄
Molecular Weight: 853.91
MDL Number: MFCD00869953
Linear Formula: C₄₇H₅₁NO₁₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-PHR1803-200MG	200 mg	$531.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to Ph. Eur. Y0000698
	traceable to USP 1491332
API family	paclitaxel
application(s)	pharmaceutical (small molecule)
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1
InChI key	RCINICONZNJXQF-MZXODVADSA-N
mp	213 °C (dec.) (lit.)
packaging	pkg of 200 mg
Quality Level	300
SMILES string	[H][C@@]12C[C@H](O)[C@@]3(C)C(=O)[C@H](OC(C)=O)C4=C(C)[C@H](C[C@@](O)([C@@H](OC(=O)c5ccccc5)[C@]3([H])[C@@]1(CO2)OC(C)=O)C4(C)C)OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7
storage temp.	2-8°C
technique(s)	gas chromatography (GC): suitable
	HPLC: suitable

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions:	Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP).
Caution:	Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions.
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAA9808 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
General description:	Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Symbol	GHS05,GHS07,GHS08
Signal word	Danger
Hazard statements	H315 - H317 - H318 - H334 - H335 - H340 - H360D - H372
Precautionary statements	P201 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

mp	213 °C (dec.) (lit.)
Storage Temp.	2-8°C
UNSPSC	41116107

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