Paclitaxel
SIAL/PHR1803 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Paclitaxel
CAS Number: 33069-62-4
Empirical Formula (Hill Notation): C47H51NO14
Molecular Weight: 853.91
MDL Number: MFCD00869953
Linear Formula: C47H51NO14
Product Type: Chemical
agency | traceable to Ph. Eur. Y0000698 |
traceable to USP 1491332 | |
application(s) | pharmaceutical (small molecule) |
CofA | current certificate can be downloaded |
format | neat |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C47H51NO14/c1-25-31(60 |
InChI key | RCINICONZNJXQF-MZXODVADSA |
mp | 213 °C (dec.) (lit.) |
packaging | pkg of 200 mg |
Quality Level | 300 ![]() |
SMILES string | [H][C@@]12C[C@H](O)[C@@]3 |
storage temp. | 2-8°C |
technique(s) | gas chromatography (GC): suitable |
HPLC: suitable |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | Paclitaxel is a potent anti-neoplastic and anti-mitotic taxane drug, which binds to the N-terminus of β-tubulin and and stabilizes microtubules arresting the cell cycle at the G2/M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A (PKA) or of Raf-1 kinase, resulting in phosphorylation of Bcl-2. A major metabolite via CYP2CB is 6α-hydroxypaclitaxel (6α-OHP). |
Caution: | Paclitaxel undergoes transesterification in methanol and hydrolyzes in aqueous solutions. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAA9808 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Symbol | ![]() ![]() ![]() |
Signal word | Danger |
Hazard statements | H315 - H317 - H318 - H334 - H335 - H340 - H360D - H372 |
Precautionary statements | P201 - P280 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
mp | 213 °C (dec.) (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |