Synonym: Sildenafil citrate salt; 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt; 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt; Revatio; UK-92,480
CAS Number: 171599-83-0
Empirical Formula (Hill Notation): C22H30N6O4S ·C6H8O7
Molecular Weight: 666.70
MDL Number: MFCD09026931
Linear Formula: C22H30N6O4S ·C6H8O7
Product Type: Chemical
agency |
traceable to Ph. Eur. Y0001578 |
|
traceable to USP 1612561 |
application(s) |
pharmaceutical (small molecule) |
CofA |
current certificate can be downloaded |
form |
solid |
grade |
certified reference material |
|
pharmaceutical secondary standard |
InChI |
1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12) |
InChI key |
DEIYFTQMQPDXOT-UHFFFAOYSA-N |
packaging |
pkg of 500 mg |
Quality Level |
300 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4 |
storage temp. |
2-8°C |
technique(s) |
gas chromatography (GC): suitable |
|
HPLC: suitable |
Analysis Note: |
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: |
Sildenafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension. NO activates guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation. Sildenafil enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP. |
Footnote: |
To see an example of a Certificate of Analysis for this material enter LRAB9121 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: |
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |