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Olmesartan Medoxomil

SIAL/PHR1851 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Olmesartan medoxomil

CAS Number: 144689-63-4
Empirical Formula (Hill Notation): C29H30N6O6
Molecular Weight: 558.59
MDL Number: MFCD00944911
Linear Formula: C29H30N6O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PHR1851-200MG 200 mg
 $277.00
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agency traceable to Ph. Eur. Y0001405
  traceable to USP 1478367
API family olmesartan
application(s) pharmaceutical
CofA current certificate can be downloaded
format neat
grade certified reference material
  pharmaceutical secondary standard
InChI 1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
InChI key UQGKUQLKSCSZGY-UHFFFAOYSA-N
packaging pkg of 200 mg
Quality Level 300 
SMILES string CCCC1=NC(C(O)(C)C)=C(C(OCC2=C(C)OC(O2)=O)=O)N1CC(C=C3)=CC=C3C4=CC=CC=C4C5=NN=NN5
storage temp. -10 to -25°C
Analysis Note: These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application: Theis pharmaceutical secondary standard can also be used as follows:

• Development and validation of an isocratic ultra-high performance liquid chromatography (UHPLC) based stability indicating method to determine olmesartan medoxomil and amlodipine besylate in combined tablet dosage forms
• Simultaneous determination of Olmesartan medoxomil and chlorthalidone by reversed phase-high performance liquid chromatography (RP-HPLC) in tablets
• Quantification of olmesartan medoxomil and its degradation products in bulk drugs and pharmaceutical formulations by using a systematic quality by design (QbD)-based reverse-phase liquid chromatography method
• Reversed phase-high performance liquid chromatographic (RP-HPLC) analysis of olmesartan medoxomil and hydrochlorothiazide in their combined tablet dosage form
• Determination of olmesartan medoxomil and amlodipine besylate in their combined tablet dosage form by absorption subtraction method, ratio subtraction with extended ratio subtraction method, dual wavelength technique, and second order derivative spectrophotometry
General description: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Olmesartan Medoxomil is an AT1 subtype angiotensin-II receptor antagonist used in the management of hypertension. It prevents angiotensin II from binding to the AT1 receptors, thereby decreasing vasoconstriction.
Other Notes: To see an example of a Certificate of Analysis for this material enter LRAC2529 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. -10 to -25°C
UNSPSC 41116107

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