Olmesartan Medoxomil

SIAL/PHR1851 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Olmesartan medoxomil

CAS Number: 144689-63-4
Empirical Formula (Hill Notation): C₂₉H₃₀N₆O₆
Molecular Weight: 558.59
MDL Number: MFCD00944911
Linear Formula: C₂₉H₃₀N₆O₆
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-PHR1851-200MG	200 mg	$257.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to BP 1173
	traceable to Ph. Eur. Y0001405
	traceable to USP 1478367
application(s)	pharmaceutical
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34)
InChI key	UQGKUQLKSCSZGY-UHFFFAOYSA-N
packaging	pkg of 200 mg
Quality Level	300
SMILES string	CCCC1=NC(C(O)(C)C)=C(C(OCC2=C(C)OC(O2)=O)=O)N1CC(C=C3)=CC=C3C4=CC=CC=C4C5=NN=NN5
storage temp.	-10 to -25°C

Analysis Note:	These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Application:	Theis pharmaceutical secondary standard can also be used as follows: • Development and validation of an isocratic ultra-high performance liquid chromatography (UHPLC) based stability indicating method to determine olmesartan medoxomil and amlodipine besylate in combined tablet dosage forms • Simultaneous determination of Olmesartan medoxomil and chlorthalidone by reversed phase-high performance liquid chromatography (RP-HPLC) in tablets • Quantification of olmesartan medoxomil and its degradation products in bulk drugs and pharmaceutical formulations by using a systematic quality by design (QbD)-based reverse-phase liquid chromatography method • Reversed phase-high performance liquid chromatographic (RP-HPLC) analysis of olmesartan medoxomil and hydrochlorothiazide in their combined tablet dosage form • Determination of olmesartan medoxomil and amlodipine besylate in their combined tablet dosage form by absorption subtraction method, ratio subtraction with extended ratio subtraction method, dual wavelength technique, and second order derivative spectrophotometry
Footnote:	To see an example of a Certificate of Analysis for this material enter LRAC2529 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
General description:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Olmesartan Medoxomil is an AT₁ subtype angiotensin-II receptor antagonist used in the management of hypertension. It prevents angiotensin II from binding to the AT₁ receptors, thereby decreasing vasoconstriction.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	-10 to -25°C
UNSPSC	12352200

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