Candesartan Cilexetil
SIAL/PHR1854 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Candesartan cilexetil; 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-
CAS Number: 145040-37-5
Empirical Formula (Hill Notation): C33H34N6O6
Molecular Weight: 610.66
MDL Number: MFCD00871371
Linear Formula: C33H34N6O6
Product Type: Chemical
| agency | traceable to Ph. Eur. Y0001388 |
| traceable to USP 1087803 | |
| API family | candesartan |
| application(s) | pharmaceutical |
| form | powder |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| InChI | 1S/C33H34N6O6/c1-3-42-32- |
| InChI key | GHOSNRCGJFBJIB-UHFFFAOYSA |
| packaging | pkg of 200 mg |
| Quality Level | 300  |
| SMILES string | CCOc1nc2cccc(C(=O)OC(C)OC |
| Analysis Note: | These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available. |
| Application: | This pharmaceutical secondary standard can also be used as follows: • Determination of candesartan cilexetil in tablet formulations by a UV/fluorescence spectrophotometric method • Study of the release of candesartan cilexetil in tablet form by reversed-phase high-performance liquid chromatography (RP-HPLC) • Simultaneous estimation of candesartan cilexetil and hydrochlorothiazide in pharmaceutical preparations using liquid chromatography in combination with photodiode array detector (DAD) and evaporative light scattering detector (ELSD) • Spectroflourimetric determination of four angiotensin II receptor antagonists (AIIRA’s) in their pure form as well as pharmaceutical formulations |
| Biochem/physiol Actions: | Candesartan cilexetil is a non-peptide angiotensin (AT2) receptor antagonist. |
| Biochem/physiol Actions: | Candesartan cilexetil is the prodrug form of the potent angiotensin II receptor antagonist, candesartan. The prodrug is cleaved by esterases within the intestine to liberate the active molecule. |
| General description: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Candesartan cilexetil is an angiotensin II receptor antagonist used as a prodrug in the treatment of hypertension. |
| Other Notes: | Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Other Notes: | To see an example of a Certificate of Analysis for this material enter LRAB8504 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
| Symbol |   GHS08,GHS09 |
| Signal word | Warning |
| Hazard statements | H361 - H400 |
| Precautionary statements | P201 - P273 - P308 + P313 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 41116107 |