Synonym: Voriconazole; 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol; UK-109496
CAS Number: 137234-62-9
Empirical Formula (Hill Notation): C16H14F3N5O
Molecular Weight: 349.31
MDL Number: MFCD00905717
Linear Formula: C16H14F3N5O
Product Type: Chemical
agency |
traceable to Ph. Eur. Y0001395 |
|
traceable to USP 1718008 |
application(s) |
pharmaceutical |
CofA |
current certificate can be downloaded |
format |
neat |
grade |
certified reference material |
|
pharmaceutical secondary standard |
InChI |
1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1 |
InChI key |
BCEHBSKCWLPMDN-MGPLVRAMSA-N |
packaging |
pkg of 1 g |
Quality Level |
300 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F |
storage temp. |
2-8°C |
Analysis Note: |
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Application: |
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
Application: |
Voriconazole may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using high-performance liquid chromatography technique. |
Biochem/physiol Actions: |
Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes. |
Footnote: |
To see an example of a Certificate of Analysis for this material enter LRAC2092 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
General description: |
Voriconazole is a synthetically prepared, broad-spectrum triazole derivative of fluconazole, which shows in vitro activity against many yeasts and a broad-spectrum of mold and dermatophyte isolates. Its mode of action involves the inhibition of cytochrome P450 (CYP)-dependent enzyme, 14-α-sterol demethylase, and hence it is involved in disrupting the cell membrane and terminate the fungal growth. |
Other Notes: |
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Storage Temp. |
2-8°C |
UNSPSC |
12352200 |