Synonym: Zoledronic acid monohydrate; P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate; Zoledronate monohydrate; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate
CAS Number: 165800-06-6
Empirical Formula (Hill Notation): C5H10N2O7P2·H2O
Molecular Weight: 290.10
MDL Number: MFCD08448695
Linear Formula: C5H10N2O7P2·H2O
Product Type: Chemical
agency |
traceable to USP 1724827 |
application(s) |
pharmaceutical |
CofA |
current certificate can be downloaded |
form |
powder |
grade |
certified reference material |
|
pharmaceutical secondary standard |
InChI |
1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2 |
InChI key |
FUXFIVRTGHOMSO-UHFFFAOYSA-N |
packaging |
pkg of 1 g |
Quality Level |
300 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O |
storage temp. |
2-30°C |
Analysis Note: |
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: |
Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones. |
Footnote: |
To see an example of a Certificate of Analysis for this material enter LRAB0346 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: |
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Storage Temp. |
2-30°C |
UNSPSC |
12352200 |