Synonym: Zoledronic acid monohydrate; P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate; Zoledronate monohydrate; [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate
CAS Number: 165800-06-6
Empirical Formula (Hill Notation): C5H10N2O7P2·H2O
Molecular Weight: 290.10
MDL Number: MFCD08448695
Linear Formula: C5H10N2O7P2·H2O
Product Type: Chemical
| agency |
traceable to USP 1724827 |
| API family |
zoledronic acid |
| application(s) |
pharmaceutical |
| CofA |
current certificate can be downloaded |
| form |
powder |
| grade |
certified reference material |
| |
pharmaceutical secondary standard |
| InChI |
1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2 |
| InChI key |
FUXFIVRTGHOMSO-UHFFFAOYSA-N |
| packaging |
pkg of 1 g |
| Quality Level |
300  |
| SMILES string |
O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O |
| storage temp. |
2-30°C |
| Analysis Note: |
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available. |
| Application: |
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements. |
| Biochem/physiol Actions: |
Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones. |
| Biochem/physiol Actions: |
Zoledronic acid (zoledronate) is a bone resorption inhibitor, an inhibitor of farnesyl diphosphate synthase |
| General description: |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
| Other Notes: |
Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial . |
| Other Notes: |
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Other Notes: |
To see an example of a Certificate of Analysis for this material enter LRAB0346 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
| Storage Temp. |
2-30°C |
| UNSPSC |
41116107 |
GHS07