Ethambutol hydrochloride

SIAL/PHR1930 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Ethambutol dihydrochloride; 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride; Emb

CAS Number: 1070-11-7
Empirical Formula (Hill Notation): C₁₀H₂₄N₂O₂ · 2HCl
Molecular Weight: 277.23
EC Number: 213-970-7
MDL Number: MFCD21364080
Linear Formula: C₁₀H₂₄N₂O₂ · 2HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1930-500MG	500 mg	$230.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to Ph. Eur. E1850000
	traceable to USP 1257007
API family	ethambutol
application(s)	pharmaceutical
CofA	current certificate can be downloaded
form	powder
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1
InChI key	AUAHHJJRFHRVPV-BZDVOYDHSA-N
packaging	pkg of 500 mg
Quality Level	300
SMILES string	CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl
storage temp.	2-30°C

Analysis Note:	These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application:	Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance.
Application:	Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China.
Biochem/physiol Actions:	Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability.
Biochem/physiol Actions:	Ethambutol specifically inhibits arabinosyltransferases in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria.
General description:	Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Other Notes:	Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial .
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Other Notes:	To see an example of a Certificate of Analysis for this material enter LRAB0956 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264 - P270 - P301 + P312 - P501
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-30°C
UNSPSC	41116107

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