Synonym: Ethambutol dihydrochloride; 2,2′-(1,2-Ethanediyldiimino)bis-1-butanol dihydrochloride; Emb
CAS Number: 1070-11-7
Empirical Formula (Hill Notation): C10H24N2O2 · 2HCl
Molecular Weight: 277.23
EC Number: 213-970-7
MDL Number: MFCD21364080
Linear Formula: C10H24N2O2 · 2HCl
Product Type: Chemical
| agency |
traceable to Ph. Eur. E1850000 |
| |
traceable to USP 1257007 |
| application(s) |
pharmaceutical |
| CofA |
current certificate can be downloaded |
| form |
powder |
| grade |
certified reference material |
| |
pharmaceutical secondary standard |
| InChI |
1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1 |
| InChI key |
AUAHHJJRFHRVPV-BZDVOYDHSA-N |
| packaging |
pkg of 500 mg |
| Quality Level |
300  |
| SMILES string |
CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl |
| storage temp. |
2-30°C |
| Analysis Note: |
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Application: |
Ethambutol is an antimycobacterial used to treat tuberculosis in combination with other antibiotics to reduce the development of drug resistance. It has been used to study multidrug-resistant tuberculosis (MDR-TB) in highest-incidence-rate areas in China. |
| Biochem/physiol Actions: |
Ethambutol is bacteriostatic against actively growing TB bacilli. Mycolic acids attach to the 5′-hydroxyl groups of D-arabinose residues of arabinogalactan and form mycolyl-arabinogalactan-peptidoglycan complex in the cell wall. Ethambutol disrupts arabinogalactan synthesis by inhibiting arabinosyltransferases, specifically those in Mycobacterium, interfering with the biosynthesis of arabinogalactans found in the cell wall of mycobacteria and leading to increased cell wall permeability. |
| Footnote: |
To see an example of a Certificate of Analysis for this material enter LRAB0956 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
| General description: |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
| Other Notes: |
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Precautionary statements |
P264 - P270 - P301 + P312 - P501 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Storage Temp. |
2-30°C |
| UNSPSC |
12352200 |
