Isoniazid
SIAL/PHR1932 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Isoniazid; 4-Pyridinecarboxylic acid hydrazide; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide
CAS Number: 54-85-3
Empirical Formula (Hill Notation): C6H7N3O
Molecular Weight: 137.14
EC Number: 200-214-6
MDL Number: MFCD00006426
Linear Formula: C6H7N3O
Product Type: Chemical
agency | traceable to BP 1083 |
traceable to Ph. Eur. I0500000 | |
traceable to USP 1349706 | |
application(s) | pharmaceutical |
CofA | current certificate can be downloaded |
form | powder |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C6H7N3O/c7-9-6(10)5-1- |
InChI key | QRXWMOHMRWLFEY-UHFFFAOYSA |
mp | 171-173 °C (lit.) |
packaging | pkg of 500 mg |
Quality Level | 300 ![]() |
SMILES string | NNC(=O)c1ccncc1 |
storage temp. | 2-8°C |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC3171 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Symbol | ![]() |
Signal word | Warning |
Hazard statements | H302 - H315 |
Precautionary statements | P264 - P270 - P280 - P301 + P312 - P302 + P352 - P332 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
mp | 171-173 °C (lit.) |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |