Tenofovir disoproxil fumarate

SIAL/PHR1957 - Pharmaceutical Secondary Standard; Certified Reference Material

Synonym: Tenofovir disoproxil fumarate; Bis(POC)PMPA fumarate; Bis{[(Isopropoxycarbonyl)oxy]methyl} ({[(2R)-1-(6-amino-9H-purin-9-yl)-2-propanyl]oxy}methyl)phosphonate fumarate

CAS Number: 202138-50-9
Empirical Formula (Hill Notation): C₁₉H₃₀N₅O₁₀P · C₄H₄O₄
Molecular Weight: 635.51
MDL Number: MFCD08141829
Linear Formula: C₁₉H₃₀N₅O₁₀P · C₄H₄O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PHR1957-500MG	500 mg	$230.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

agency	traceable to USP 1643656
API family	tenofovir
application(s)	pharmaceutical
CofA	current certificate can be downloaded
format	neat
grade	certified reference material
	pharmaceutical secondary standard
InChI	1S/C19H30N5O10P.C4H4O4/c1-12(2)33-18(25)28-9-31-35(27,32-10-29-19(26)34-13(3)4)11-30-14(5)6-24-8-23-15-16(20)21-7-22-17(15)24;5-3(6)1-2-4(7)8/h7-8,12-14H,6,9-11H2,1-5H3,(H2,20,21,22);1-2H,(H,5,6)(H,7,8)/b;2-1+/t14-;/m1./s1
InChI key	VCMJCVGFSROFHV-WZGZYPNHSA-N
packaging	pkg of 500 mg
Quality Level	300
SMILES string	OC(/C=C/C(O)=O)=O.NC1=C2C(N(C[C@@H](C)OCP(OCOC(OC(C)C)=O)(OCOC(OC(C)C)=O)=O)C=N2)=NC=N1
storage temp.	2-8°C

Analysis Note:	These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Application:	These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions:	Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. In a T cell line and primary blood lymphocytes, the antiviral activity of tenofovir disoproxil was shown to be more than 100-fold greater than tenofovir because of its rapid intracellular uptake. Tenofovir disoproxil fumarate has been used alone and in various combinations for the prevention and treatment of HIV/AIDS and chronic hepatitis B infections and is on the World Health Organization′s List of Essential Medicines.
Biochem/physiol Actions:	Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor (nRTI); anti-retroviral.
General description:	Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Other Notes:	This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Other Notes:	To see an example of a Certificate of Analysis for this material enter LRAB2763 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	41116107

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