Tenofovir disoproxil fumarate
SIAL/PHR1957 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Tenofovir disoproxil fumarate; Bis(POC)PMPA fumarate; Bis{[(Isopropoxycarbonyl)
CAS Number: 202138-50-9
Empirical Formula (Hill Notation): C19H30N5O10P · C4H4O4
Molecular Weight: 635.51
MDL Number: MFCD08141829
Linear Formula: C19H30N5O10P · C4H4O4
Product Type: Chemical
agency | traceable to USP 1643656 |
application(s) | pharmaceutical |
CofA | current certificate can be downloaded |
format | neat |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C19H30N5O10P.C4H4O4/c1 |
InChI key | VCMJCVGFSROFHV-WZGZYPNHSA |
packaging | pkg of 500 mg |
Quality Level | 300 ![]() |
SMILES string | OC(/C=C/C(O)=O)=O.NC1=C2C |
storage temp. | 2-8°C |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | Tenofovir disoproxil fumarate is a prodrug of tenofovir, a nucleotide analogue reverse transcriptase inhibitor (nRTI) that causes premature termination of DNA transcription. In a T cell line and primary blood lymphocytes, the antiviral activity of tenofovir disoproxil was shown to be more than 100-fold greater than tenofovir because of its rapid intracellular uptake. Tenofovir disoproxil fumarate has been used alone and in various combinations for the prevention and treatment of HIV/AIDS and chronic hepatitis B infections and is on the World Health Organization′s List of Essential Medicines. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAB2763 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |