Nicotinamide Impurity F
SIAL/PHR2091 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: 1-Methylnicotinamide chloride; 3-
CAS Number: 1005-24-9
Empirical Formula (Hill Notation): C7H9ClN2O
Molecular Weight: 172.61
Linear Formula: C7H9ClN2O
Product Type: Chemical
form | powder |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C7H8N2O.ClH/c1-9-4-2-3 |
InChI key | BWVDQVQUNNBTLK-UHFFFAOYSA |
packaging | pkg of 100 mg |
storage temp. | 2-30°C |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT). 1-Methylnicotinamide (MNA) has been shown to have antithrombotic and anti-inflammatory effects. A recent study indicated that MNA may exert antithrombotic and anti-inflammatory effects through direct action on the endothelium, with a vasorelaxing effect by enhancement of NO bioavailability and reduction of eNOS-dependent oxidative stress. Enhanced NNMT activity is a feature of many types of cancer. How much direct involvement MNA has in the tumorigenesis associated with overexpression of NNMT is under investigation. MNA by itself increased mitochondrial Complex I activity and increased cancer cell viability in SH-SY5Y neuroblastoma cells that do not produce NNMT. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAB9787 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-30°C |
UNSPSC | 41116107 |