Hydroxyurea
SIAL/PHR2629 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Hydroxyurea; Hydroxycarbamide
CAS Number: 127-07-1
Empirical Formula (Hill Notation): CH4N2O2
Molecular Weight: 76.05
MDL Number: MFCD00007943
Linear Formula: NH2CONHOH
Product Type: Chemical
agency | traceable to BP BP197 |
traceable to Ph. Eur. Y0000119 | |
traceable to USP 1332000 | |
CofA | current certificate can be downloaded |
form | solid |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/CH4N2O2/c2-1(4)3-5/h5H |
InChI key | VSNHCAURESNICA-UHFFFAOYSA |
packaging | pkg of 300 mg |
SMILES string | NC(=O)NO |
storage temp. | 2-8°C |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC5960 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Symbol | GHS08 |
Signal word | Danger |
Hazard statements | H340 - H361 |
Precautionary statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 41116107 |