Lysophosphatidylcholine
SIAL/PHR2631 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: L-α-Lysophosphatidylcholine from egg yolk; 1-Acyl-sn-
CAS Number: 9008-30-4
MDL Number: MFCD00131444
Product Type: Chemical
| agency | traceable to Ph. Eur. Y0001904 |
| traceable to USP 1372050 | |
| form | solid |
| grade | certified reference material |
| pharmaceutical secondary standard | |
| packaging | pkg of 250 mg |
| storage temp. | -10 to -25°C |
| Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
| Biochem/physiol Actions: | Lysophosphatidylcholine is a major component of oxidized low density lipoproteins, and has been implicated in various inflammatory reactions, including atherosclerosis. It is used to demyelinate spinal neurons and study the processes underlying remyelination. It activates protein kinase C, p38 MAP kinase, p42 MAP Kinase, and the jun kinase (JNK) pathway, and stimulates transcription of c-jun. Lysophosphatidylcholine accumulates during cardiac ischemia and may induce arrhythmias by uncoupling gap junction communication, and increase ischemic damage by enhancing Na+ loading in cardiac myocytes. It also activates TREK1, TREK2 and TRAAK K+ channels. |
| General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
| Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | -10 to -25°C |
| UNSPSC | 41116107 |