Streptomycin Sulfate
SIAL/PHR2687 - certified reference material, pharmaceutical secondary standard
Synonym: Streptomycin sulfate salt
CAS Number: 3810-74-0
Empirical Formula (Hill Notation): C21H39N7O12 · 1.5H2O4S
Molecular Weight: 728.69
MDL Number: MFCD00037023
Linear Formula: C21H39N7O12 · 1.5 H2SO4
Product Type: Chemical
agency | traceable to Ph. Eur. S1400000 |
traceable to USP 1623003 | |
CofA | current certificate can be downloaded |
description | Pharmaceutical Secondary Standard; Certified Reference Material |
form | solid |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/2C21H39N7O12.3H2O4S/c2 |
InChI key | QTENRWWVYAAPBI-YZTFXSNBSA |
packaging | pkg of 500 mg |
SMILES string | OS(O)(=O)=O.OS(O)(=O)=O.O |
storage temp. | -10 to -25°C |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | Mode of Action: Streptomycin acts by inhibiting prokaryote protein synthesis by binding to the S12 protein of the 30S ribosomal subunit, thus preventing the transition from imitation complex to chain-elongating ribosome. This causes miscoding or inhibits initiation. Mode of Resistance: A mutation in rpsL, a gene for S12 ribosomal protein, prevents binding of streptomycin to the ribosome. An aminoglycoside phosphotransferase also inactivates streptomycin. Antimicrobial spectrum: Streptomycin acts against gram-negative and gram-positive bacteria. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Symbol | ![]() ![]() |
Signal word | Warning |
Hazard statements | H302 - H361fd |
Precautionary statements | P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313 |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | -10 to -25°C |
UNSPSC | 41116107 |