Fingolimod Hydrochloride
SIAL/PHR2790
Synonym: FTY720; 2-
CAS Number: 162359-56-0
Empirical Formula (Hill Notation): C19H33NO2 · HCl
Molecular Weight: 343.93
Linear Formula: C19H33NO2 · HCl
Product Type: Chemical
agency | traceable to Ph. Eur. Y0002055 |
traceable to USP 1270480 | |
description | Pharmaceutical Secondary Standard; Certified Reference Material |
form | powder |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C19H33NO2.ClH/c1-2-3-4 |
InChI key | SWZTYAVBMYWFGS-UHFFFAOYSA |
packaging | pkg of 500 mg |
storage temp. | 2-30°C |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | FTY720 is an immunomodulating drug and sphingosine 1-phosphate (S1P) receptor modulator. Phosphorylation of FTY270 by sphingosine kinase causes S1P1R internalization, which sequesters lymphocytes in lymph nodes, preventing them from taking part in an autoimmune response. Clinically, it has been approved for the treatment of multiple sclerosis (MS). It has also been shown to block and reverse paclitaxel-induced chemotherapy induced peripheral neuropathy (CIPN) through S1PR inhibition as well as inhibit the activity of histone deacetylases in the hippocampus of mouse brains, thereby modulating memory. |
Footnote: | To see an example of a Certificate of Analysis for this material enter LRAC6340 in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Storage Temp. | 2-30°C |