Nitazoxanide
SIAL/PHR2888 - pharmaceutical secondary standard, certified reference material
Synonym: Nitazoxanide; NTZ; 2-
CAS Number: 55981-09-4
Empirical Formula (Hill Notation): C12H9N3O5S
Molecular Weight: 307.28
MDL Number: MFCD00416599
Linear Formula: C12H9N3O5S
Product Type: Chemical
agency | traceable to USP 1463960 |
application(s) | pharmaceutical |
CofA | current certificate can be downloaded |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C12H9N3O5S/c1-7(16)20- |
InChI key | YQNQNVDNTFHQSW-UHFFFAOYSA |
packaging | pkg of 400 mg |
SMILES string | CC(=O)Oc1ccccc1C(=O)Nc2nc |
storage temp. | 2-8°C |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | Nitazoxanide is an inhibitor of pyruvate-ferredoxin oxidoreductase (PFOR); Antimicrobial recently found to kill both non-replicating and replicating mycobacteria. FDA approved anti-parasitic drug (2002). Recent work (C & EN Sept. 14, 2009, p. 28) highlights that NTZ kills non-replicating and replicating TB bacteria and no apparent resistance is detected. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Storage Temp. | 2-8°C |