Rosiglitazone
SIAL/PHR2932 - Pharmaceutical Secondary Standard; Certified Reference Material
Synonym: Rosiglitazone; 5-
CAS Number: 122320-73-4
Empirical Formula (Hill Notation): C18H19N3O3S
Molecular Weight: 357.43
MDL Number: MFCD00871760
Linear Formula: C18H19N3O3S
Product Type: Chemical
agency | traceable to USP 1605817 |
form | solid |
grade | certified reference material |
pharmaceutical secondary standard | |
InChI | 1S/C18H19N3O3S/c1-21(16-4 |
InChI key | YASAKCUCGLMORW-UHFFFAOYSA |
packaging | pkg of 300 mg |
SMILES string | CN(CCOc1ccc(CC2SC(=O)NC2= |
storage temp. | 2-8°C |
Analysis Note: | These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: | Rosiglitazone is a potent agonist for PPARγ with an EC50 of 43 nM for the human receptor. It is antidiabetic, working as an insulin sensitizer by binding to the PPARγ receptors in fat cells and making the cells more responsive to insulin. |
General description: | Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: | This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
Storage Temp. | 2-8°C |