Synonym: Methazolamide; 5-Acetylimino-4-methyl-ยท2-1,3,4-thiadiazoline-2-sulfonamide; N-(4-Methyl-2-sulfamoyl-Δ2-1,3,4-thiadiazolin-5-ylidene) acetamide; L 584601; N-[5-(Aminosulfonyl)-3-methyl-1,3,4-thiadiazol-2(3H)-ylidene]acetamide
CAS Number: 554-57-4
Empirical Formula (Hill Notation): C5H8N4O3S2
Molecular Weight: 236.27
MDL Number: MFCD00083416
Linear Formula: C5H8N4O3S2
Product Type: Chemical
agency |
traceable to USP 1406005 |
application(s) |
pharmaceutical |
CofA |
current certificate can be downloaded |
grade |
certified reference material |
|
pharmaceutical secondary standard |
InChI |
1S/C5H8N4O3S2/c1-3(10)7-4-9(2)8-5(13-4)14(6,11)12/h1-2H3,(H2,6,11,12)/b7-4+ |
InChI key |
FLOSMHQXBMRNHR-QPJJXVBHSA-N |
mp |
208 °C (dec.) (lit.) |
packaging |
pkg of 1 g |
Quality Level |
300 ![External link](https://krackeler.com/images/sigma/ext-link.gif) |
SMILES string |
CN1N=C(SC1=NC(C)=O)S(N)(=O)=O |
storage temp. |
2-30°C |
Analysis Note: |
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available. |
Biochem/physiol Actions: |
Methazolamide is a cell-permeable and potent carbonic anhydrase (CA) inhibitor that is used in the treatment of glaucoma. Methazolamide is an insulin sensitizer that reduces hepatic glucose generation in animal models. |
Footnote: |
To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive. |
General description: |
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards |
Other Notes: |
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis. |
mp |
208 °C (dec.) (lit.) |
Storage Temp. |
2-30°C |