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Deferoxamine Mesylate

SIAL/PHR3411 - certified reference material, pharmaceutical secondary standard

Synonym: Deferoxamine mesylate salt; DFOM; Deferoxamine methanesulfonate salt; Desferrioxamine mesylate salt

CAS Number: 138-14-7
Empirical Formula (Hill Notation): C25H48N6O8 · CH4O3S
Molecular Weight: 656.79
MDL Number: MFCD00058605
Linear Formula: C25H48N6O8 · CH4O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PHR3411-500MG
No Price  

 

application(s) pharmaceutical
CofA current certificate can be downloaded
grade certified reference material
  pharmaceutical secondary standard
InChI 1S/C25H48N6O8.CH4O3S/c1-21(32)29(37)18-9-3-6-16-27-22(33)12-14-25(36)31(39)20-10-4-7-17-28-23(34)11-13-24(35)30(38)19-8-2-5-15-26;1-5(2,3)4/h37-39H,2-20,26H2,1H3,(H,27,33)(H,28,34);1H3,(H,2,3,4)
InChI key IDDIJAWJANBQLJ-UHFFFAOYSA-N
packaging pkg of 500 mg
Quality Level 300 
SMILES string CS(O)(=O)=O.CC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCNC(=O)CCC(=O)N(O)CCCCCN
Analysis Note: These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Biochem/physiol Actions: An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells against H2O2-induced damage.
Footnote: To see an example of a Certificate of Analysis for this material enter LRAA6959(changes by product) in the Documents slot below. This is an example certificate only and may not be the lot that you receive.
General description: Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Other Notes: This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

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