Acetylcholine chloride
SIAL/RDD043 - ≥99% (TLC), free-flowing, Redi-Dri™
Synonym: ACh
CAS Number: 60-31-1
Empirical Formula (Hill Notation): C7H16ClNO2
Molecular Weight: 181.66
MDL Number: MFCD00011698
Linear Formula: (CH3)3N+CH2CH2OCOCH3Cl-
Product Type: Chemical
| assay | ≥99% (TLC) |
| InChI | 1S/C7H16NO2.ClH/c1-7(9)10 |
| InChI key | JUGOREOARAHOCO-UHFFFAOYSA |
| mp | 146-150 °C (lit.) |
| product line | Redi-Dri™ |
| quality | free-flowing |
| Quality Level | 100  |
| SMILES string | [Cl-].CC(=O)OCC[N+](C)(C) |
| solubility | H2O: 100 mg/mL |
| Application: | Acetylcholine chloride has been used: • as an agent to trigger sudomotor axon reflex response during autonomic test • to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats • as a substrate for acetylcholinesterase • to stimulate after discharge in Aplysia bag cell neurons |
| Biochem/physiol Actions: | Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6. |
| Caution: | Very hygroscopic |
| General description: | Acetylcholine is a neurotransmitter released at nerve endings in both the central and peripheral nervous systems. Acetylcholine chloride (C7H16ClNO2) is a stable cholinergic agonist with muscarinic and nicotinic actions. It is available as white or off-white hygroscopic crystals, or as a crystalline powder. Acetylcholine chloride is hygroscopic in nature and is highly soluble in water, alcohol, propylene glycol and chloroform. |
| Legal Information: | Redi-Dri is a trademark of Sigma-Aldrich Co. LLC |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99% (TLC) |
| mp | 146-150 °C (lit.) |
| UNSPSC | 12352200 |