Sulfobromophthalein disodium salt hydrate

SIAL/S0252 - used to study hepatocyte transport functions

Synonym: BSP; Bromsulfalein sodium disodium salt hydrate

CAS Number: 123359-42-2
Empirical Formula (Hill Notation): C₂₀H₈Br₄Na₂O₁₀S₂ · xH₂O
Molecular Weight: 838.00 (anhydrous basis)
EC Number: 200-761-0
MDL Number: MFCD00150017
Linear Formula: C₂₀H₈Br₄Na₂O₁₀S₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S0252-5G	5 g	$517.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

λ_max	575-581 nm
application(s)	diagnostic assay manufacturing hematology histology
color	white to light gray
composition	Water (by Karl Fischer): ≤ 8% Sodium (Na) anhydrous: 4.6-5.8%
form	powder
InChI	1S/C20H10Br4O10S2.2Na.H2O/c21-15-13-14(16(22)18(24)17(15)23)20(34-19(13)27,7-1-3-9(25)11(5-7)35(28,29)30)8-2-4-10(26)12(6-8)36(31,32)33;;;/h1-6,25-26H,(H,28,29,30)(H,31,32,33);;;1H2/q;2*+1;/p-2
InChI key	CDTNUNQQEUGDSD-UHFFFAOYSA-L
Quality Level	200
SMILES string	[Na+].[Na+].[H]O[H].Oc1ccc(cc1S([O-])(=O)=O)C2(OC(=O)c3c(Br)c(Br)c(Br)c(Br)c23)c4ccc(O)c(c4)S([O-])(=O)=O
solubility	water: 50 mg/mL (clear to very hazy)
storage temp.	room temp
technique(s)	titration: suitable

Application:	Sulfobromophthalein disodium salt hydrate has been used as a positive control to study the interaction of 11-keto-β-boswellic acid (KBA) and 3-acetyl-11-keto-β-boswellic acid (AKBA) with organic anion transporter OATP1B3.
Biochem/physiol Actions:	Sulfobromophthalein (BSP) is a high affinity organic ion substrate for organic anion transporting polypeptides (OATPs) and has been used as a substrate for multidrug resistance associated protein 2 (Mrp2). BSP is transported into hepatocytes by OATPs and, after conjugation to glutathione, is excreted into bile by Mrp2. It was found to inhibit the aldo-keto reductase ARK1C20.
Packaging:	5 g in glass bottle

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P342 + P311
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	room temp
UNSPSC	12171500

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