Novobiocin Ready Made Solution
SIAL/SBR00025 - 100 mg/mL in water
Synonym: Novobiocin Ready Made Solution
Empirical Formula (Hill Notation): C31H35N2NaO11
Molecular Weight: 634.61
Linear Formula: C31H35N2NaO11
Product Type: Chemical
| antibiotic activity spectrum | Gram-negative bacteria |
| Gram-positive bacteria | |
| mycobacteria | |
| neoplastics | |
| assay | ≥90% |
| biological source | microbial |
| concentration | 100 mg/mL in water |
| form | liquid |
| mode of action | DNA synthesis | interferes |
| enzyme | inhibits | |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Novobiocin, a member of aminocoumarin antibiotics, is naturally produced by Streptomyces niveus. Novobiocin is a well-known inhibitor of bacterial DNA gyrase and mammalian topoisomerase, ATP-dependent enzymes involved in cell division. It can be used in cell culture systems to treat mycoplasma contaminations. Furthermore, Novobiocin has an anti-cancer effects through Hsp90 (heat shock protein) inhibition., In addition, novobiocin shows a minimum inhibitory effect 0.25-16 μg/mL against gram positive and negative bacteria. |
| Preparation Note: | Novobiocin Ready Made Solution is light sensitive. Thaw this product at room temperature. It is recommended to avoid repeated freeze thaw cycles of this product. The suggested concentration of Novobiocin for cell culture assays is 50-1000 μg/mL,,, therefore, it is recommended to dilute the Ready Made Solution 1:100-2000. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H317 |
| Precautionary statements | P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364 |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥90% |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |