Ligstroside
SIAL/SBR00026 - Nitric oxide inhibitor, ≥95%
Synonym: Ligustroside
CAS Number: 35897-92-8
Empirical Formula (Hill Notation): C25H32O12
Molecular Weight: 524.51
Linear Formula: C25H32O12
Product Type: Chemical
| assay | ≥95% |
| form | lyophilized powder |
| Quality Level | 100  |
| solubility | DMSO: ≥10 mg/mL (19 mM) |
| methanol: ≥10 mg/mL | |
| storage temp. | −20°C |
| Biochem/physiol Actions: | Ligstroside is a natural product derived from leaves of Olea europaea. Ligstroside displays several potentially beneficial anti-inflammatory properties by exhibiting selective inhibition effect on COX-1 enzyme of arachidonate cascade metabolism. Ligstroside generates a reduction of the PGE2 (prostaglandin E2) levels in activated mouse macrophage (IC50 = 48.53 μM) and also reduction of the TXB2 (thromboxane B2) levels in human platelets (IC50 = 122.63 μM). Moreover, Ligstroside exhibits inhibition activity of NO production in LPS-activated RAW264.7 macrophages (17.8% at 30 μM and 40.7% at 100 μM) without any cytotoxic effect in these cells., Additionally, Ligstroside exhibits in vitro antiviral activity against parainfluenza type 3 virus (IC50 = 15.6 μM). |
| Storage and Stability: | Hygroscopic; store in dry place with desiccant |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |