5′-Hydroxy carvedilol

SIAL/SMB00929 - ≥95% (HPLC)

Synonym: 5′-Hydroxy carvedilol; 3-[2-[[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl]amino]ethoxy]-4-methoxyphenol; 5′-Hydroxyphenyl carvedilol; 5′-Hydroxyphenyl carvedilol; 5′-Hydroxyphenylcarvedilol; 5′-OH carvedilol; 5-Hydroxycarvedilol; 5OHC; BM-140830; Carvedilol metabolite M5

CAS Number: 142227-51-8
Empirical Formula (Hill Notation): C₂₄H₂₆N₂O₅
Molecular Weight: 422.47
Linear Formula: C₂₄H₂₆N₂O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-SMB00929-10MG	10 mg	$563.00 1/EA	Add To Favorites
45-SMB00929-50MG	50 mg	$2820.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95% (HPLC)
color	off-white
form	solid
Quality Level	100
solubility	DMSO: soluble, clear, colorless
storage temp.	2-8°C

General description:

Carvedilol is a β- and α1-adrenoreceptor blocker for the treatment of hypertension and congestive heart failure (CHF). The drug is metabolized by CYP2D6 (to 4′-OH and 5′-OH), CYP2C9 (to O-desmethyl), CYP1A2 (to 8-OH). It is also oxidized to 1-OH carvedilol, but the enzyme involved is not yet clear. These metabolites are useful markers for studying and monitoring the activities of cytochrome metabolizing enzymes. M4 metabolite (4′-OH), but not M2 or M5, is most likely to contribute to total β-adrenoceptor blocking activity due to its higher potency.

WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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