5-Methoxy-L-tryptophan
SIAL/SMB00930 - 98-102%
Synonym: 5-
CAS Number: 25197-96-0
Empirical Formula (Hill Notation): C12H14N2O3
Molecular Weight: 234.25
Linear Formula: C12H14N2O3
Product Type: Chemical
| assay | 98-102% |
| color | off-white to light yellow |
| form | solid |
| optical activity | [α]20/D -30 to -28° in water |
| Quality Level | 100  |
| storage temp. | 2-8°C |
| General description: | 5-Methoxy-L-tryptophan is a L-tryptophan metabolite that exhibits anti-inflammatory and tumor-suppressing activities. 5-Methoxy-L-tryptophan is synthesized by tryptophan hydroxylase (TPH) and hydroxyindole O-methyltransferase (HIOMT). Recent study indicates 5-methoxytryptophan as a biomarker of progression of chronic kidney disease (CKD). Its levels decrease during disease and treatment with 5-methoxytryptophan ameliorates kidney fibrosis n mice model of CKD. 5-Methoxytryptophan appears to inhibit I?B/NF-?B signaling and enhaces Keap1/Nrf2 signaling in mice model of unilateral ureteral obstruction. Literature often uses the name 5-Methoxytryptophan instead L-5-Methoxytryptophan. |
| Symbol |  GHS06 |
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301 + P310 + P330 |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 98-102% |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |